Home | Services | Medical Dermatology | Intralesional Methotrexate

Intralesional Methotrexate is used for the treatment of squamous cell carcinoma, keratoacanthoma, and basal cell carcinoma. This treatment is effective for quickly growing tumors because it works by slowing the growth of cancer cells. It is a great alternative to surgery, as it is less invasive, as well as less costly. In other cases, it may be used to shrink a tumor while waiting for surgery, reducing the extent of the surgery.

Who is a Good Candidate for Intralesional Methotrexate?

While surgery is often the treatment of choice for skin cancers, in some cases, it may not be the best option. Individuals with squamous cell carcinoma, keratoacanthoma, or basal cell carcinoma can benefit from intralesional methotrexate. Before treatment, be sure to tell your dermatologist if you are pregnant, plan on becoming pregnant, or are breastfeeding, have low blood cell counts, have a weak immune system, or have cirrhosis or chronic liver disease.

What to Expect During Intralesional Methotrexate Treatment?

During intralesional methotrexate treatment, your dermatologist will inject the methotrexate solution directly into the lesion, which will feel like a small pinch. Sometimes blood work will be ordered prior to commencing with therapy. The injections require multiple visits spaced a few weeks apart, though this may differ from patient to patient. Your dermatologist will inform you on how to properly receive intralesional methotrexate treatments for the best possible results.

Following Intralesional Methotrexate Treatment

There is no downtime required following intralesional methotrexate treatment, so patients can go about their everyday routines. Methotrexate may cause some side effects, including dizziness, headache, decreased appetite, hair loss, or swollen or tender gums. If these occur, please contact our office right away, as we may need to adjust the dose of treatment or discontinue treatment. Do not hesitate to contact our office if you have any questions or concerns regarding treatment.

Schedule a Consultation

If you have been diagnosed with squamous cell carcinoma, keratoacanthoma, and basal cell carcinoma, and are interested in learning more about intralesional methotrexate as a treatment option, contact our office today. Our team will be happy to assist you in scheduling your consultation appointment, which is the first step toward treatment. During this appointment, you will be able to discuss your symptoms and treatment options with your dermatologist or physician assistant, and  the best treatment option will be chosen.

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