Glucagon-like peptide-1 (GLP-1) receptor agonists—such as Ozempic, Wegovy, and Zepbound—have become game changers for managing type 2 diabetes and weight loss. But do these medications have any affect on your skin? At HMGS Dermatology, we’re committed to helping you understand the connections between these medications and your skin health. Psoriasis, hidradenitis suppurativa, alopecia, and fat redistribution can all be impacted by GLPs.
How Do GLP-1 Medications Affect Your Skin?
GLP-1 receptor agonists work by mimicking a natural hormone that helps regulate blood sugar, control appetite, and support weight loss. Recent research shows these medications also have anti-inflammatory effects that may benefit certain skin diseases. However, they can also trigger side effects, including changes to hair and skin quality.
Skin-Related Effects of GLP-1s:
- Injection site reactions (redness, itching, rash)
- Improvement in inflammatory skin conditions like psoriasis and hidradenitis suppurativa
- Potential for hair loss due to rapid weight loss or nutritional deficiencies
- Skin laxity, loss of facial/buttock fat volume
Will My Psoriasis Improve on GLP-1s?
Psoriasis is a chronic inflammatory skin condition often linked to obesity. Studies show that individuals with higher body mass index (BMI) are more likely to develop psoriasis, and excess weight can result in more severe of disease and worsen symptoms. GLP-1 medications may help by reducing inflammation and supporting weight loss, both of which can improve psoriasis severity.
- GLP-1s lower pro-inflammatory cytokines involved in psoriasis.
- Weight loss through GLP-1s can reduce psoriasis flares.
- Some patients see improvement in psoriasis even before significant weight loss, suggesting a direct anti-inflammatory effect.
- We have seen patients on both GLP-1s and biologic medications (eg Taltz, Skyrizi) see remarkable improvement in their psoriasis
Will My Hidradenitis Suppurativa Improve on GLP-1s?
Hidradenitis suppurativa (HS) is another inflammatory skin disease strongly associated with obesity. Higher body weight increases skin friction and inflammation, both of which can trigger or worsen HS symptoms. Evidence suggests that weight loss—whether through lifestyle changes or GLP-1 medications—may reduce the severity and frequency of HS flares for some patients.
- Obesity is a known risk factor for HS.
- GLP-1s may help by promoting weight loss and reducing inflammation.
- Not everyone with HS will see improvement, but weight management is a key part of care.
Will My Hair Fall Out on GLP-1s ?
Rapid weight loss, especially when using GLP-1 medications, can sometimes lead to hair loss (alopecia). This is usually a temporary condition called telogen effluvium, where hair sheds over a period of months due to physiological or emotional stress. Key points:
- Hair loss is commonly triggered by rapid weight loss, not the medication itself.
- Insufficient intake of nutrients like iron, zinc, and protein can worsen hair thinning.
- Most cases are reversible with proper nutrition and stabilization of weight.
If you’re experiencing hair loss while on GLP-1s, consult your dermatologist for a specific diagnosis and a tailored approach to restore healthy hair growth.
Will I Develop an “Ozempic Face” or “Ozempic Butt”on GLP-1s?
While GLP-1 medications like Ozempic, Wegovy, and Zepbound are effective for weight loss, rapid fat reduction can sometimes lead to changes in body appearance that some patients find undesirable. “Ozempic face” and “Ozempic butt” are two colloquial terms that have been used to describe skin laxity and loss of volume. These changes are not dangerous but can impact self-esteem and body image.
HMGS Dermatology Viewpoints on GLP-1s:
At HMGS Dermatology, we recognize the dual impact of GLP-1 medications on both metabolic and skin health. Our expert team stays updated on the latest research to help you manage skin conditions related to obesity and weight loss. Whether you have concerns about psoriasis, hidradenitis suppurativa, hair loss, or skin appearance we’re here to guide you every step of the way.
Take Charge of Your Skin Health Today!
If you’re using GLP-1 medications and have questions about your skin or hair, don’t wait. Contact HMGS Dermatology to schedule a consultation. Our board-certified dermatologists are here to help with compassionate, expert care.
- Learn more about psoriasis care
- Explore hidradenitis suppurativa treatment options
- Find answers about alopecia and hair loss
Your journey to healthier skin starts here—visit HMGS Dermatology today!
